The freight and logistics sector supports economic development in the Greater Mekong Subregion (GMS). Against this background, the efficiency, environmental performance and safety of dangerous goods transport of the sector become important to ensure countries continue to grow, increase the welfare, maintain their economic competitiveness, and reduce environmental and social impacts. Freight sector studies conducted under the ADB’s GMS Core Environment Program (GMS CEP), reveal that the movement of freight has increased by 75% between 2002 and 2011, and exports of goods from the GMS almost tripled in the same period. Infrastructure expansion further increases transport and traffic activities. The corresponding rise in fuel consumption has increased GHG emissions and the dependency on oil imports. Surveys of freight companies show that fuel consumption costs often account for 40%-60% of the operating costs. In order to ensure sustainable development of the sector as well as the supply chains of the transported goods, efficiency and safety improvements are needed. Green freight interventions have shown that 5-15% improvement in efficiency is possible. The project has been designed based on the vision, objectives and priorities of various key institutions in the region. Workshops and preparatory meetings between the key players have been conducted to prepare this project. This project builds on and complements ongoing projects under the GMS CEP which are currently testing green freight interventions, driver behaviour improvements and logistics efficiency solutions. In addition, It will replicate the successful adaptation of the European Agreement concerning the International Carriage of Dangerous Goods (ADR) in Thailand to the other countries.